Correlation analysis between ETCO2 and lactate level showed significantly strong negative correlation (correlation coefficient =-0.852, p=0.001). Most of most of the patients had compensated metabolic acidosis (82.9%). Subjects’ case was 35.7% called for resuscitation, 32.9% was septic shock with surgery, 17.1% was septic shock without surgery, and 14.3% was hypovolemic shock with surgery. Results: There were 70 subjects analyzed with median age 55 years old. We did an association test to determine ther relation between ETCO2 level and lactate level in such patients. ETCO2 measurement by capnograph, lactate level measurement, and blood good analysis were done to all eligible patients. Subjects were hemodinamicaly unstable patients aged 13-90 years old without primary pulmonary diseases recruited by consecutive sampling. Method: This was observational, cross sectional study conducted on January to February 2017 in Sanglah General Hospital, Bali, Indonesia. Objective: This study aimed to search the correlation between ETCO2 level and hyperlactatemia in patients with hemodynamic disturbance. High ETCO2 was hypothesized as related to hyperlactatemia, thus monitoring of ETCO2 could be a non-invasive monitoring in hemodynamically unstable patients. Decreased PaCO2 as the consequence of hyperventilation can be measured as end-tidal CO2 (ETCO2). Hyperlactatemia induces metabolic acidosis, which then compensated by hyperventilation. Background: Critically ill and hemodynamically unstable patients usually have perfusion disturbance that causes anerobic metabolism, causing increased lactate production.
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